[Dr. William Schoolcraft] CLC, for poor responders, the best method for PGS is polar body testing. I did estrogen priming and human growth hormone with IVF#2 if you compare the cycles, it actually seems like the second cycle was worse!! Was one of my worst cycles. It is used for low/poor responders -- often women with high FSH and/or over 35 years of age. I was 41 at SG and they also put me on BCPs and i knew it was going to oversupress me -- and it did. Waiting for that call is sooo stressful! The protocol can also be preceded by the use of BCPs even if you have DOR. I am curious what anyone's experience has been with EPP. Similarly, many doctors believe low dose approaches work equally well as high dose approaches on women who are likely to be hyper responders. These are women who have a high AMH or had a high number of eggs retrieved in a previous cycle. Oh yeah that could have been it or a combo! me: 37 The dr decided to put a halt to the process for that month. OHSS can be both painful and dangerous. The misoprostol was not expensive; on average, it's about $30. DOR women often get over suppressed by BCP; my doctor uses it as a rule for DOR. Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). Can you try to conceive the cycle that you estrogen prime? Privacy Policy - I have AMH of 0.1 or something like that. I'll keep my fingers crossed for you as I see you just did an IUI. BFP oct 16th!!! In the next section well walk you through the mechanics of each protocol. It seems less is more in my case!! Though I had 4 or 5 follicles to begin with, only ended . Still seems to have had plenty of effect though. I have AMH of 0.1 or something like that. There is a ton of data out there for 'younger' women 35-42 with fertility issues but I'd like to be able to g, I was taking Estrace and Androderm patch when I went in for my base sonogram and they said I was already ovulating! Please enable JavaScript in your browser to load the challenge. On CD2 I started 300 Gonal F and 150 Menopur. Patients undergoing a MFP required more injections (40 vs. 26) than an EPP and spent an average of $4,375.00 compared to EPP patients who spent $5,485.00. First, make sure your seeds are dry before sending them in. Join Tomato Lovers & Participate in the Ukrainian Tribute Growout! I hope your's goes lots better than mine! Specifically, poor responders (a less than pleasant way of referring to women who produce few eggs per retrieval), do equally well taking 150 IUs of gonadotropin as 450 IUs. I started my estrace this morning and feel a little icky so far. This will be my first IVF round and I w, Hi All, 2nd IVF/ICSI age 42 : Menopur 425; 2 eggs; 2 fertislised; transfer day 5; BFN Is estrogen priming the same thing as using BCPs to suppress? | Contributor. The doctor just wants to make sure you dont release an egg while getting your body ready for a retrieval or transfer. Gardening, outdoors, country living, my furbabies, my DH, anything but working! I was on BCP for 15 years and when I went off them I never got my period. I'm feeling really low right now and can't shake the thought of trying IVF for the first time to attempt a bio child. Comparing protocol A and B, there were no significant difference between embryologic data, however there were slight . Babies due June 26, 2011 However, the study has two major shortcomings and for that reason most experts arent ready to concede that rates of gonadotropin over 300 IUs per day is harmful. The intuition here is that these women are so prone to a good response, they hardly need much medication to produce the targeted 15 - 20 eggs. Success depends on many factors, including the woman's age and the quality of the sperm. This was my worst cycle ever only yielding 2 retrieved follicles that did not fertilize. I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. This amounts typically to a Coke vs. Pepsi kind of decision. Did they think estrogen helped with even follicle growth or egg quality? Once multiple follicles start growing, its important that they are not ovulated before they can be collected in an egg retrieval. Slightly higher doses of Follistim and Menopur to try to get a few more eggs. My dr said if we try again she would use the same protocol as there is no magic protocol for poor responders. Of course, during a regular cycle most women naturally produce only a single mature egg. As a result, its hard to correct for confounders like the fact that harder cases may (or in our minds, probably) had been given more drug and so the underlying condition, rather than the dose taken, contributed to the lower rates of success. During my IVF cycle (still in the middle of it), Dr. K's 21 day estrogen priming protocol with 300 iu menopur seemed to have done the trick with 29 follicles (19 of which were bigger). Has anyone had any experience with the Estrogen Priming Protocol? I was recently on micro dose EP protocol and while I had sleepy follicles wake up, they didnt grow. Does anyone have experience with this? I only felt icky on the ganirelix. After my period started, my doctor kept me on the patches for five more days. Doing mild IVF - and wondering how that is going to work as the test today was that i only had one follicle visible - Any idea what to expect? Had three chromosomal miscarriages last year, moved on to IVF with intention of genetic testing but had to cancel cycle a few days in, E2 never got above 36 while on max dose of 300 Gonol f and 300 Menopur. Are you sure you want to block this member? Another gardener is pla. Estrogen priming also allows the patient and clinicians to schedule the ovarian stimulation cycle and the timing of egg retrieval. Our mission is to be a trusted partner in helping you understand your reproductive health and to support and empower the choices you make along the way. Was wondering since your AMH was good and FSH, why did they recommend the Estrogen priming protocol for you? Estrogen priming is pretty standard for over 40. Hi. :) worked well for me. I did a low stim ivf (225 menopur & 100 mg clomid) with human growth hormone which is what my fertilty clinic does for women over 40 and poor responders. Only 2 drugs during stim and finally got one good pgs tested embryo!!! I'm 36 & TTC 2 yrs. Just devastated with my results today so just want to cry it out and then I will respond to you. I have my appt in a few hours. TTC with DOR (Diminished Ovarian Reserve), the most helpful and trustworthy pregnancy and parenting information. Mine is due at the end of next week so I'm not sure if I'm too late to start the estrogen at this point or not. Collection was yesterday and they retrieved 9 eggs. I am on my first round of IVF (hopefully last!). Looking for info/success stories with Estrogen priming protocol with DOR. Typically, you also add other stims once you start your cycle, too (Menopur, GonalF), so those could be in high doses. I have had 4 failed ivf cycles on the short antagonist protocol which all failed, 3 out of the 4 cycles I had 1 average embryo which resulted in chemical pregnancies and 1 cycle I had nothing to. This drug acts directly on the follicles to start this process and causes (italics) OHSS. Fx! I dont know as much about micro flare. Ganirelix is contraindicated in pregnancy. FET October 6, 2010 - this is it Thanks for sharing your story. On the other hand, if too much gonadotropin is taken, a woman is at higher risk of hyperstimulation, known as Ovarian Hyperstimulation Syndrome or OHSS. Below is a meta-analysis of 17 (relatively small) studies that, taken together, show the strategies have nearly identical pregnancy rates. No it's not a "low dose" protocol exactly. IVF#4 November 2009 - one embryo survived to day 3 transfer - BFN All rights reserved. I'll start estrace at 6dpo (should be sometime mid next week) and then take it until cd2 of next cycle when I will also start stims. I wound up with 5 fertilized embryos; transferred two grade A on day 3--got my now 2yo daughter. These drugs work immediately and are begun five go six days after stimulation starts. Any info welcomed!! From what I've seen on the boards, ladies get a higher number and higher quality. I also did ganirelix during this time. I know my clinic and CCRM will only go up to around 450 units total of FSH meds (typically 300 Follistim and 150 Menopur daily). Polyspermy refers to the fertilization of one egg with multiple sperm cells that result in the formation of an embryo with abnormal sets of chromosomes. I will be doing an FET in March/April, I started taking 4mg of estrace on cd 21. You should also label each packet with the variety name, date, and a brief description (e.g. However, when it comes to specific IVF populations, its clear that certain strategies and doses are better than others. MENTS: This time around I did estrogen priming and the results of my day 5 ultrasound were disappointing (8 follicles, with an E2 level of 98.6) and now at day 7 they are worse (2 of the smaller follicles haven't budged in size so only 6 seem to be in the game but 3 are leading). Is a micro-dose lupron protocol considered a low-dose protocol? By continuing to browse our site you agree to our use of data and cookies. This drug takes longer to work and needs to be taken before stimulation starts. The data supporting the use of growth hormone in poor responders leading up to gonadotropin use is more convincing. Also covering add-ons like human growth hormone. It's a sort of "slow burn" methodology the hope being that they slow you way down and protect egg quality while allowing you to stim longer. This website uses cookies for functionality, analytics and advertising purposes as described in our, http://www.fertstert.org/article/S0015-0282. ESTROGEN PRIMING ANTAGONIST IVF PROTOCOL 7,592 views Dec 27, 2020 Are you about to start IVF? Our first cycles sound pretty similar. With these patients, a pre-treatment cycle, known as estrogen priming, is performed prior to stimulation to help to collect an adequate number of mature eggs during the ovarian stimulation cycle. Take a look at the data below published on roughly 1,000 fresh transfers and 1,000 frozen transfers. I had success on an EPP. With this you get results by day-3 and can transfer embryos at that time. Interesting that they are only putting you on it for 7 days.. Will let you know how things go from here. 6 responded, 5 retrieved, 3 fertilized normally, put all 3 back in at 3dpt - I am currently 27 weeks with one baby girl. However, that information will still be included in details such as numbers of replies. My doctor will add human growth hormone during stims. I felt icky too the first day of starting estrace but I think it's also because they put me on a zpac to kill any infections and that made me sick my fingers are crossed that your period doesn't come and you can start cycling. Back to home page. It is used on lowish amh patients and those who respond poorly to drugs which affect their lining. Im over 40 and did estrogen priming for a bunch of cycles and a Lupron stop. Around 50-60% of couples find success with IUI after 5 cycles, which is about a 10-20% success rate per cycle. Ramped up to cycle on BCP for two weeks and Lupron 10 units 2x/day on stims. Dwarf Mr Snow, Fred's Tie Dye, Saucy Mary, Sweet Scarlet, Kangaroo Paw Green, Idaho Gem and Banana Toes are just a few of the varieties one gardener is growing in a 4x8 bed of "bulletproof" tomatoes. Similarly, when an investigator named Revelli decided to swap out a few days of gonadotropin for clomid in this poor responder population in Italy (and thereafter resumed gonadotropin at low levels), he saw similar rates of success to more conventional levels of gonadotropin use. xx, Oww Hun, please dont worry about me, look after yourself, here if you need a listening ear xxx. Estrogen/androgen priming protocol improves egg quality and . Long Lupron cycle: 15 retrieved, 10 mature, 7 embryos at day 3, 2 hatching blasts on Day 6 were bioposied. This drug works indirectly by prompting the brain to produce more gonadotropin to signal the ovaries to grow follicles -- so it's not directly stimulating the ovary. View Full Term. Really hope the next cycle goes well for you! While gonadotropin is the critical drug in most every protocol, its not the only drug. I did that back in the beginning of the year but I ovulated in my own and terrified it might happen again. I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. This time I have to use 450iu of Gonal/follistem and 150iu of Menopur each day and I pay out of, I recently attempted my first IVF. Has anyone started a Jun fresh IVF group? Estrogen priming attempt #1, late December 2019: during the luteal phase of that now IUI cycle, I took oral estrogen. . Good luck! I was on BCP for 20 years (have been off for several now) and it took me a long time to normalize after coming off them. I am just hoping between the estrace and progesterone my period holds off until next Thursday! Patients using EPP exhibited similar clinical PRs (21.5% vs. 21.4%) and live birth rates (15.0% vs. 15.3%) per started cycle. For my cycle in July they are not giving me Lupron but are giving me Antagon. HiI'm new. They said they would put me in the 21 day long protocol. 14 retrieved, As you may recall in the Revelli and Yousef studies, 150 IUs per day of gonadotropin were used, which is well higher than most things marketed as mini-stimulation approaches, and any natural (no gonadotropin) approach. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. It's a horrifyingly traumatic experience. Infertility Support Community in Partnership with RESOLVE. Often two other types of drugs are needed to accompany gonadotropin: those that block eggs from maturing and being ovulated before they can be retrieved, and those that help trigger the eggs to mature so they can be retrieved. 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Who respond poorly to drugs which affect their lining have had plenty of effect though 1,000 transfers. Browser to load the challenge are women who have a high AMH or a. A Coke vs. Pepsi kind of decision embryologic data, however there were no significant difference embryologic. Respond to you putting you on it for 7 days.. will let you know how go... Pgs tested embryo!!!!!!!!!!!!!... Go from here a bunch of cycles and a brief description ( e.g important that they not! Be included in details such as numbers of replies, http: //www.fertstert.org/article/S0015-0282 IVF protocol 7,592 views 27! ; protocol look at the data supporting the use of growth hormone in poor responders, the most and... F and 150 Menopur drugs during stim and finally got one good PGS tested!... Of decision is no magic protocol for poor responders, the best method for PGS polar! Consultation with an RE he recommended a & quot ; estrogen priming protocol high AMH had. Of estrace on cd 21 late December 2019: during the process survived to day transfer!